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Confronting Pancreatic Cancer

Select Abstractssm for Pancreatic Cancer

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Select highlights of recent findings in pancreatic cancer treatment and research presented monthly and which may include clinical trial results, research findings, cancer treatment studies and those addressing other issues which are of interest in cancer of the pancreas.

These presentations are NOT meant to be taken as recommendations in any manner, but rather are offered to help provide a sense of the growing edge of cancer research as pertaining to pancreatic cancer treatment, diagnosis and care. And also to give attention to some of the more current interesting, unusual or even offbeat studies. Please read the Pancreatica Disclaimer.

 

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2008


FEBRUARY

Biweekly Triple Combination Chemotherapy with Gemcitabine, Oxaliplatin, Levofolinic Acid and 5-Fluorouracil (GOLF) is a Safe and Active Treatment.
Correale P, Montagnani F, Miano S, Sciandivasci A, Pascucci A, Petrioli R, Testi W, Tanzini G, Francini G.
J Chemother. 2008 Feb;20(1):119-25. Siena University School of Medicine, Italy.
[Link to Abstract]

Full-Dose Gemcitabine with Concurrent Radiation Therapy in Patients with Nonmetastatic Pancreatic Cancer: A Multicenter Phase II Trial.
Small W Jr, Berlin J, Freedman GM, Lawrence T, Talamonti MS, Mulcahy MF, Chakravarthy AB, Konski AA, Zalupski MM, Philip PA, Kinsella TJ, Merchant NB, Hoffman JP, Benson AB, Nicol S, Xu RM, Gill JF, McGinn CJ.
J Clin Oncol. 2008 Feb 20;26(6):942-7. Northwestern University, Chicago, Illinois.
[Link to Abstract]

 


Pilot Study of Mutant Ras Peptide-Based Vaccine as an Adjuvant Treatment in Pancreatic and Colorectal Cancers.
Toubaji A, Achtar M, Provenzano M, Herrin VE, Behrens R, Hamilton M, Bernstein S, Venzon D, Gause B, Marincola F, Khleif SN.
Cancer Immunol Immunother. [Epub] 2008 Feb 23. Vaccine Branch, NCI, NIH, NNMC, Bethesda, Maryland.
[Link to Abstract]

Treatment with Combined Streptozotocin and Liposomal Doxorubicin in Metastatic Endocrine Pancreatic Tumors.
Fjällskog ML, Janson ET, Falkmer UG, Vatn MH, Oberg KE, Eriksson BK.
Neuroendocrinology. [Epub] 2008 Feb 18. Uppsala University, Sweden.
[Link to Abstract]


JANUARY

Irinotecan Plus Gemcitabine and 5-Fluorouracil in Advanced Pancreatic Cancer: A Phase II Study.
Endlicher E, Troppmann M, Kullmann A, Golder S, Herold T, Herfarth H, Grossmann J, Schlottmann K, Kullmann F.
Oncology. 2007;72(5-6):279-84. Epub 2008 Jan 11. University of Regensburg, Germany.
[Link to Abstract]

Neoadjuvant Chemoradiation in Patients with Potentially Resectable Pancreatic Cancer.
Takai S, Satoi S, Yanagimoto H, Toyokawa H, Takahashi K, Terakawa N, Araki H, Matsui Y, Sohgawa M, Kamiyama Y.
Pancreas. 2008 Jan;36(1):e26-32. Kansai Medical University, Hirakata-City, Osaka, Japan.
[Link to Abstract]


A Phase II Study of Capecitabine Plus Gemcitabine in Patients with Locally Advanced or Metastatic Pancreatic Cancer.
Song HS, Do YR, Chang HM, Ryu MH, Lee KH, Kim YH, Hong DS, Cho JY, Lee KE, Kim SY.
Cancer Chemother Pharmacol. Epub 2008 Jan 3. Dongsan Medical Center, Keimyung University School of Medicine, Dongsan-Dong, Chung-Gu, Daegu, South Korea.
[Link to Abstract]

Preoperative Chemoradiation in Adenocarcinoma of the Pancreas. A Single Centre Experience Advocating a New Treatment Strategy.
Golcher H, Brunner T, Grabenbauer G, Merkel S, Papadopoulos T, Hohenberger W, Meyer T.
Eur J Surg Oncol. Epub 2008 Jan 9. University of Erlangen, Germany.
[Link to Abstract]


2007


DECEMBER

3D Radiotherapy Can Be Safely Combined with Sandwich Systemic Gemcitabine Chemotherapy in the Management of Pancreatic Cancer: Factors Influencing Outcome.
Spry N, Harvey J, Macleod C, Borg M, Ngan SY, Millar JL, Graham P, Zissiadis Y, Kneebone A, Carroll S, Davies T, Reece WH, Iacopetta B, Goldstein D.
Int J Radiat Oncol Biol Phys., Epub: Dec 28, 2007. Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
[Link to Abstract]

Clinical Efficacy of Intra-Arterial Pharmacokinetic Chemotherapy with 5-Fluorouracil, CDDP, Gemcitabine, and Angiotensin-II in Patients with Advanced Pancreatic Cancer.
Ishikawa T, Kamimura H, Tsuchiya A, Togashi T, Watanabe K, Seki K, Ohta H, Yoshida T, Takeda K, Kamimura T.
Hepatogastroenterology. 2007 Dec;54(80):2378-82. Saiseikai Niigata Second Hospital, Niigata, Japan.
[Link to Abstract]

Erlotinib/Gemcitabine for First-Line Treatment of Locally Advanced Or Metastatic Adenocarcinoma of the Pancreas.
Senderowicz AM, Johnson JR, Sridhara R, Zimmerman P, Justice R, Pazdur R.
Oncology (Williston Park). 2007 Dec;21(14):1696-706; discussion 1706-9, 1712, 1715. Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
[Link to Abstract]

Use of Octreotide for the Prevention of Pancreatic Fistula After Elective Pancreatic Surgery: A Systematic Review and Meta-Analysis.
Alghamdi AA, Jawas AM, Hart RS.
Can J Surg. 2007 Dec;50(6):459-66. University of Toronto, Ontario, Canada.
[Link to Abstract]

NOVEMBER

Capecitabine in Combination with Docetaxel and Mitomycin C in Patients with Pre-Treated Tumours: Results of an Extended Phase-I Trial.
Ernst T, Merx K, Gnad-Vogt U, Lukan N, Kripp M, Schultheis B, Hochhaus A, Hofheinz RD.
Br J Cancer. 2007 Dec 3;97(11):1475-9; Epub 2007 Nov 13. Medizinische Fakultät Mannheim der Universität Heidelberg, Germany.
[Link to Abstract]

Long-Term Survival on Capecitabine in Two Gemcitabine Refractory Pancreatic Cancer Patients. Is There a Pharmacogenetic Explanation?
Saif MW, Kang SP, Ledbetter L, Steg A, Diasio R, Johnson M.
JOP. 2007 Nov 9;8(6):799-805. Yale University School of Medicine. New Haven, Connecticut; University of Alabama at Birmingham, Alabama.
[Link to Abstract]

Poxvirus-Based Vaccine Therapy for Patients with Advanced Pancreatic Cancer.
Kaufman HL, Kim-Schulze S, Manson K, DeRaffele G, Mitcham J, Seo KS, Kim DW, Marshall J.
J Transl Med. 2007 Nov 26;5:60. Division of Surgical Oncology, Columbia University, New York.
[Link to Abstract]

Transarterial Chemoperfusion with Gemcitabine and Mitomycin C in Pancreatic Carcinoma: Results in Locally Recurrent Tumors and Advanced Tumor Stages.
Vogl TJ, Zangos S, Heller M, Hammerstingl RM, Böcher E, Jacob U, Bauer RW.
Rofo. 2007 Nov;179(11):1181-8. Institut für Diagnostische und Interventionelle Radiologie, J. W. Goethe-Universität Frankfurt, Germany.
[Link to Abstract]

OCTOBER

Phase I and Pharmacokinetic Study of Imatinib Mesylate (Gleevec) and Gemcitabine in Patients with Refractory Solid Tumors.
Ali Y, Lin Y, Gharibo MM, Gounder MK, Stein MN, Lagattuta TF, Egorin MJ, Rubin EH, Poplin EA.
Clin Cancer Res. 2007 Oct 1;13(19):5876-82. The Cancer Institute of New Jersey, University of Medicine & Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey.
[Link to Abstract]

Phase I Dose-Finding Study of Weekly Docetaxel Followed by Flavopiridol for Patients with Advanced Solid Tumors.
Fornier MN, Rathkopf D, Shah M, Patil S, O'Reilly E, Tse AN, Hudis C, Lefkowitz R, Kelsen DP, Schwartz GK.
Clin Cancer Res. 2007 Oct 1;13(19):5841-6. Memorial Sloan-Kettering Cancer Center, New York.
[Link to Abstract]

Phase I Study of Oxaliplatin, Full-Dose Gemcitabine, and Concurrent Radiation Therapy in Pancreatic Cancer.
Desai SP, Ben-Josef E, Normolle DP, Francis IR, Greenson JK, Simeone DM, Chang AE, Colletti LM, Lawrence TS, Zalupski MM.
J Clin Oncol. 2007 Oct 10;25(29):4587-92. University of Michigan, Ann Arbor.
[Link to Abstract]

Capecitabine Plus Erlotinib in Gemcitabine-Refractory Advanced Pancreatic Cancer.
Kulke MH, Blaszkowsky LS, Ryan DP, Clark JW, Meyerhardt JA, Zhu AX, Enzinger PC, Kwak EL, Muzikansky A, Lawrence C, Fuchs CS.
J Clin Oncol. 2007 Oct 20;25(30):4787-92. Dana-Farber Cancer Institute, Boston, Massachusetts.
[Link to Abstract]

SEPTEMBER

Complete Remission of a Metastatic Pancreatic Carcinoma after Modified G-FLIP Therapy.
Alldinger I, Tsamaloukas AG, Germing U, Hosch SB, Knoefel WT.
Chemotherapy. 2007;53(5):356-9.Epub 2007 Sep 3. University Hospital Dusseldorf, Germany.
[Link to Abstract]

Curcumin Augments Gemcitabine Cytotoxic Effect on Pancreatic Adenocarcinoma Cell Lines.
Lev-Ari S, Vexler A, Starr A, Ashkenazy-Voghera M, Greif J, Aderka D, Ben-Yosef R.
Cancer Invest. 2007 Sep;25(6):411-8. Tel-Aviv University, Israel.
[Link to Abstract]

Efficacy of Preoperative Radiochemotherapy in Patients with Locally Advanced Pancreatic Carcinoma.
Lind PA, Isaksson B, Almström M, Johnsson A, Albiin N, Byström P, Permert J.
Acta Oncol. Epub 2007 Sep 20;:1-8. Karolinska-Stockholm Söder Hospital, Stockholm, Sweden.
[Link to Abstract]

Neoadjuvant Chemotherapy and Radiation for Patients with Locally Unresectable Pancreatic Adenocarcinoma: Feasibility, Efficacy, and Survival.
Allendorf JD, Lauerman M, Bill A, Digiorgi M, Goetz N, Vakiani E, Remotti H, Schrope B, Sherman W, Hall M, Fine RL, Chabot JA.
J Gastrointest Surg. Epub 2007 Sep 5. Columbia University College of Physicians and Surgeons, New York.
[Link to Abstract]

A Phase I Study of Erlotinib in Combination with Gemcitabine and Radiation in Locally Advanced, Non-Operable Pancreatic Adenocarcinoma.
Duffy A, Kortmansky J, Schwartz GK, Capanu M, Puleio S, Minsky B, Saltz L, Kelsen DP, O'reilly EM.
Ann Oncol. Epub 2007 Sep 17. Memorial Sloan-Kettering Cancer Center, New York.
[Link to Abstract]

AUGUST

Arterial Infusion of 5-Fluorouracil Combined with Concurrent Radiotherapy for Unresectable Pancreatic Cancer: Results From a Pilot Study.
Tanaka T, Sakaguchi H, Anai H, Yamamoto K, Morimoto K, Tamamoto T, Kichikawa K.
AJR Am J Roentgenol. 2007 Aug;189(2):421-8. Nara Medical University, Kashihara, Japan.
[Link to Abstract]

Effect of Low-Molecular-Weight Heparin on Survival in Patients with Advanced Pancreatic Adenocarcinoma.
von Delius S, Ayvaz M, Wagenpfeil S, Eckel F, Schmid RM, Lersch C.
Thromb Haemost. 2007 Aug;98(2):434-9. Technical University of Munich, Germany.
[Link to Abstract]

Meta-Analysis on Gemcitabine of Fixed-Dose Rate Infusion Plus Oxaliplatin as First-Line Therapy for Advanced Pancreatic Cancer.
Xie DR, Liang HL, Yang Q, Guo SS, Jiang ZM.
Ai Zheng. 2007 Aug;26(8):895-9. The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
[Link to Abstract]

Phase I Trial of Fixed Dose Rate Infusion Gemcitabine with Gefitinib in Patients with Pancreatic Carcinoma.
Carneiro BA, Brand RE, Fine E, Knop RH, Khandekar JD, Uhlig W, Locker GY.
Cancer Invest. 2007 Aug;25(5):366-71. Kellogg Cancer Care Center, Evanston Northwestern Healthcare, Evanston, Illinois.
[Link to Abstract]

JULY

Correlation Between Development of Rash and Efficacy in Patients Treated with the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib in Two Large Phase III Studies.
Wacker B, Nagrani T, Weinberg J, Witt K, Clark G, Cagnoni PJ.
Clin Cancer Res. 2007 Jul 1;13(13):3913-21. OSI Pharmaceuticals, Boulder, Colorado.
[Link to Abstract]

Laparoscopic Radiofrequency Ablation of Neuroendocrine Liver Metastases: A 10-Year Experience Evaluating Predictors of Survival.
Mazzaglia PJ, Berber E, Milas M, Siperstein AE.
Surgery. 2007 Jul;142(1):10-9. Rhode Island Hospital, Providence, Rhode Island.
[Link to Abstract]

Phase II Study of Capecitabine with Concomitant Radiotherapy for Patients with Locally Advanced Pancreatic Cancer: Up-Regulation of Thymidine Phosphorylase.
Saif MW, Black G, Roy S, Bell D, Russo S, Eloubeidi MA, Steg A, Johnson MR, Zelterman D, Diasio RB.
Cancer J. 2007 Jul-Aug;13(4):247-56. Yale University School of Medicine, New Haven, Connecticut.
[Link to Abstract]

Phase II Trial of Weekly Docetaxel/Irinotecan Combination in Advanced Pancreatic Cancer.
Burtness B, Thomas L, Sipples R, McGurk M, Salikooti S, Christoforou M, Mirto G, Salem R, Sosa J, Kloss R, Rahman Z, Chung G, Lacy J, Murren JR.
Cancer J. 2007 Jul-Aug;13(4):257-62. Fox Chase Cancer Center, Philadelphia, Pennsylvania.
[Link to Abstract]

JUNE

Concurrent Chemoradiotherapy for Advanced Pancreatic Cancer : 1,000 Mg/M(2) Gemcitabine Can Be Administered Using Limited-Field Radiotherapy.
Yamazaki H, Nishiyama K, Koizumi M, Tanaka E, Ioka T, Uehara H, Iishi H, Nakaizumi A, Ohigashi H, Ishikawa O.
Strahlenther Onkol. 2007 Jun;183(6):301-306. Medical Center for Cancer and Cardiovascular Disease, Japan.
[Link to Abstract]

Dosimetric Feasibility of Hypofractionated Proton Radiotherapy for Neoadjuvant Pancreatic Cancer Treatment.
Kozak KR, Kachnic LA, Adams J, Crowley EM, Alexander BM, Mamon HJ, Fernandez-Del Castillo C, Ryan DP, Delaney TF, Hong TS.
I Int J Radiat Oncol Biol Phys. 2007 Aug 1;68(5):1557-66. [Epub ahead of print June 4, 2007]. Massachusetts General Hospital, Boston.
[Link to Abstract]

A New Liposomal Formulation of Gemcitabine is Active in an Orthotopic Mouse Model of Pancreatic Cancer Accessible to Bioluminescence Imaging.
Bornmann C, Graeser R, Esser N, Ziroli V, Jantscheff P, Keck T, Unger C, Hopt UT, Adam U, Schaechtele C, Massing U, von Dobschuetz E.
Cancer Chemother Pharmacol. [Epub ahead of print June 7,2007]. Albert-Ludwigs-University Freiburg, Germany.
[Link to Abstract]

Successful Pancreatectomy with En-Bloc Resection of the Celiac Artery and Portal Vein for Pancreatic Endocrine Carcinoma.
Akatsu T, Aiura K, Shimazu M, Ueda M, Wakabayashi G, Tanabe M, Kawachi S, Shinoda M, Kameyama K, Kitajima M, Kitagawa Y.
IHepatogastroenterology. 2007 Jun;54(76):1269-71. Keio University School of Medicine, Tokyo, Japan.
[Link to Abstract]

MAY

3,3',5-Triiodo-L-Thyronine Inhibits Ductal Pancreatic Adenocarcinoma Proliferation Improving the Cytotoxic Effect of Chemotherapy.
Michienzi S, Bucci B, Verga Falzacappa C, Patriarca V, Stigliano A, Panacchia L, Brunetti E, Toscano V, Misiti S.
J Endocrinol. 2007 May;193(2):209-23. University La Sapienza, Rome, Italy.
[Link to Abstract]

Erlotinib Plus Gemcitabine Compared with Gemcitabine Alone in Patients with Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group.
Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR, Gallinger S, Au HJ, Murawa P, Walde D, Wolff RA, Campos D, Lim R, Ding K, Clark G, Voskoglou-Nomikos T, Ptasynski M, Parulekar W.
IJ Clin Oncol. 2007 May 20;25(15):1960-6. Princess Margaret Hospital, Toronto, Canada.
[Link to Abstract]

Hp39p Use of the Superficial Femoral Vein as a Conduit for Portal Vein Reconstruction During Pancreaticoduodenectomy.
Gillespie C, Jauffret B.
ANZ J Surg. 2007 May;77 Suppl 1:A48-9. Gisborne Hospital, New Zealand.
[Link to Abstract]

Phase II Trial of Infusional Fluorouracil, Leucovorin, Mitomycin, and Dipyridamole in Locally Advanced Unresectable Pancreatic Adenocarcinoma: SWOG S9700.
Isacoff WH, Bendetti JK, Barstis JJ, Jazieh AR, Macdonald JS, Philip PA.
J Clin Oncol. 2007 May 1;25(13):1665-9. University of California, Los Angeles Medical Center.
[Link to Abstract]

APRIL

Erbb3 Expression and Dimerization with EGFR Influence Pancreatic Cancer Cell Sensitivity to Erlotinib.
Frolov A, Schuller K, Tzeng CW, Cannon EE, Ku BC, Howard JH, Vickers SM, Heslin MJ, Buchsbaum DJ, Arnoletti JP.
Cancer Biol Ther. 2007 Apr 13;6(4) [Epub]. University of Alabama at Birmingham, Alabama.
[Link to Abstract]

The Gemcitabine, Docetaxel, and Capecitabine (GTX) Regimen for Metastatic Pancreatic Cancer: A Retrospective Analysis.
Fine RL, Fogelman DR, Schreibman SM, Desai M, Sherman W, Strauss J, Guba S, Andrade R, Chabot J.
Cancer Chemother Pharmacol. 2007 Apr 18; [Epub]. New York Presbyterian Medical Center, Columbia University College of Physicians and Surgeons, New York.
[Link to Abstract]

A Phase I Pilot Study of Autologous Heat Shock Protein Vaccine HSPPC-96 in Patients with Resected Pancreatic Adenocarcinoma.
Maki RG, Livingston PO, Lewis JJ, Janetzki S, Klimstra D, Desantis D, Srivastava PK, Brennan MF.
Dig Dis Sci. 2007 Apr 10; [Epub]. Memorial Sloan- Kettering Cancer Center, New York.
[Link to Abstract]

A Randomized Phase 2 Trial of Neoadjuvant Chemotherapy in Resectable Pancreatic Cancer: Gemcitabine Alone Versus Gemcitabine Combined with Cisplatin.
Palmer DH, Stocken DD, Hewitt H, Markham CE, Hassan AB, Johnson PJ, Buckels JA, Bramhall SR.
Ann Surg Oncol. 2007 Jul;14(7):2088-96. 2007 Apr 24; [Epub]. Cancer Research UK Institute for Cancer Studies and Clinical Trials Unit, University of Birmingham, UK.
[Link to Abstract]

MARCH

Full-Dose Gemcitabine and Concurrent Radiotherapy for Unresectable Pancreatic Cancer.
Murphy JD, Adusumilli S, Griffith KA, Ray ME, Zalupski MM, Lawrence TS, Ben-Josef E.
Int J Radiat Oncol Biol Phys. 2007 Mar 20, Epub. University of Michigan, Ann Arbor, MI, USA.
[Link to Abstract]

A Phase II Study of Fixed-Dose Rate Gemcitabine Plus Low-Dose Cisplatin Followed by Consolidative Chemoradiation for Locally Advanced Pancreatic Cancer.
Ko AH, Quivey JM, Venook AP, Bergsland EK, Dito E, Schillinger B, Tempero MA.
Int J Radiat Oncol Biol Phys. 2007 Mar 13, Epub. University of California at San Francisco, CA, USA.
[Link to Abstract]

A Phase II Trial of Gemcitabine Plus Capecitabine for Patients with Advanced Pancreatic Adenocarcinoma.
Park BB, Park JO, Lee HR, Lee J, Choi DW, Choi SH, Heo JS, Lee JK, Lee KT, Lim DH, Park YS, Lim HY, Kang WK, Park K.
Cancer Chemother Pharmacol. 2007 Mar 30, Epub. Sungkyunkwan University School of Medicine, Seoul, South Korea.
[Link to Abstract]

Pooled Efficacy Analysis from a Phase I-II Study of Biweekly Irinotecan in Combination with Gemcitabine, 5-Fluorouracil, Leucovorin and Cisplatin in Patients with Metastatic Pancreatic Cancer.
Goel A, Grossbard ML, Malamud S, Homel P, Dietrich M, Rodriguez T, Mirzoyev T, Kozuch P.
Anticancer Drugs. 2007 Mar;18(3):263-71. St Luke's-Roosevelt Hospital Center, New York, NY, USA.
[Link to Abstract]

FEBRUARY

Aggressive Surgery Improves Long-Term Survival in Neuroendocrine Pancreatic Tumors: An Institutional Experience.
Schurr PG, Strate T, Rese K, Kaifi JT, Reichelt U, Petri S, Kleinhans H, Yekebas EF, Izbicki JR.
Ann Surg. 2007 Feb;245(2):273-81. University Medical Center of Hamburg-Eppendorf, University of Hamburg, Germany.
[Link to Abstract]

FOLFOX-6 Combination as the First-Line Treatment of Locally Advanced and/or Metastatic Pancreatic Cancer.
Ghosn M, Farhat F, Kattan J, Younes F, Moukadem W, Nasr F, Chahine G.
Am J Clin Oncol. 2007 Feb;30(1):15-20. Hotel-Dieu de France University Hospital, Beirut, Lebanon.
[Link to Abstract]

In Vitro and In Vivo Molecular Evidence of Genistein Action in Augmenting the Efficacy of Cisplatin in Pancreatic Cancer.
Banerjee S, Zhang Y, Wang Z, Che M, Chiao PJ, Abbruzzese JL, Sarkar FH.
Int J Cancer. 2007 Feb 15;120(4):906-17. Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
[Link to Abstract]

Low-Dose Radiotherapy as a Chemopotentiator of Gemcitabine in Tumors of the Pancreas or Small Bowel: A Phase I Study Exploring a New Treatment Paradigm.
Regine WF, Hanna N, Garofalo MC, Doyle A, Arnold S, Kataria R, Sims J, Tan M, Mohiuddin M.
Int J Radiat Oncol Biol Phys. 2007 May 1;68(1):172-7. [Epub 2007 Feb 2]. University of Maryland, Baltimore, Maryland.
[Link to Abstract]


JANUARY

Clinical and In Vitro Studies of Imatinib in Advanced Carcinoid Tumors.
Yao JC, Zhang JX, Rashid A, Yeung SC, Szklaruk J, Hess K, Xie K, Ellis L, Abbruzzese JL, Ajani JA.
Clin Cancer Res. 2007 Jan 1;13(1):234-40. The University of Texas / M.D. Anderson Cancer Center, Houston, Texas.
[Link to Abstract]

Impact of Interferon-Alpha in Combined Chemoradioimmunotherapy for Pancreatic Adenocarcinoma (Capri): First Data from the Immunomonitoring.
Schmidt J, Jager D, Hoffmann K, Buchler MW, Marten A.
J Immunother. 2007 Jan;30(1):108-15. University of Heidelberg, Germany.
[Link to Abstract]

Phase I Study of Oral S-1 and Concurrent Radiotherapy in Patients with Unresectable Locally Advanced Pancreatic Cancer.
Sudo K, Yamaguchi T, Ishihara T, Nakamura K, Shirai Y, Nakagawa A, Kawakami H, Uno T, Ito H, Saisho H.
Int J Radiat Oncol Biol Phys. 2007 Jan 1;67(1):219-24. Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan.
[Link to Abstract]

Second-Line Chemotherapy with Pemetrexed After Gemcitabine Failure in Patients with Advanced Pancreatic Cancer: A Multicenter Phase II Trial.
Boeck S, Weigang-Kohler K, Fuchs M, Kettner E, Quietzsch D, Trojan J, Stotzer O, Zeuzem S, Lordick F, Kohne CH, Kroning H, Steinmetz T, Depenbrock H, Heinemann V.
Ann Oncol. 2007 Apr;18(4):745-51. Epub 2007 Jan 17. University Hospital Grosshadern, Ludwigs-Maximilians University, Munich, Germany.
[Link to Abstract]


2006


DECEMBER

An Aggressive Surgical Approach Leads to Long-Term Survival in Patients with Pancreatic Endocrine Tumors.
Fendrich V, Langer P, Celik I, Bartsch DK, Zielke A, Ramaswamy A, Rothmund M.
Ann Surg. 2006 Dec;244(6):845-51; discussion 852-3. Philipps-University Marburg, Germany.
[Link to Abstract]

Erlotinib Plus Gemcitabine in Patients with Unresectable Pancreatic Cancer and Other Solid Tumors: Phase IB Trial.
Dragovich T, Huberman M, Von Hoff DD, Rowinsky EK, Nadler P, Wood D, Hamilton M, Hage G, Wolf J, Patnaik A.
Cancer Chemother Pharmacol. 2006 Dec 6, Epub. University of Arizona, Tucson, Arizona.
[Link to Abstract]

Low Molecular Weight Heparin (LMWH) Increases the Efficacy of Cisplatinum Plus Gemcitabine Combination in Advanced Pancreatic Cancer.
Icli F, Akbulut H, Utkan G, Yalcin B, Dincol D, Isikdogan A, Demirkazik A, Onur H, Cay F, Buyukcelik A.
J Surg Oncol. 2006 Dec 27, Epub. Ankara University School of Medicine, Turkey.
[Link to Abstract]

Phase II Study of Cisplatin Combined With Weekly Gemcitabine in the Treatment of Patients with Metastatic Pancreatic Carcinoma.
Bang S, Jeon TJ, Kim MH, Park JY, Park SW, Chung JB, Song SY.
Pancreatology. 2006 Dec 6;6(6):635-641, Epub. Yonsei University College of Medicine, Seoul, Korea.
[Link to Abstract]

FOLFIRI.3, A New Regimen Combining 5-Fluorouracil, Folinic Acid and Irinotecan, for Advanced Pancreatic Cancer: Results of an Association Des Gastro-Enterologues Oncologues (Gastroenterologist Oncologist Association) Multicenter Phase II Study.
Taieb J, Lecomte T, Aparicio T, Asnacios A, Mansourbakht T, Artru P, Fallik D, Spano J, Landi B, Lledo G, Desrame J.
Ann Oncol. 2006 Dec 8, Epub. Groupe Hospitalier Pitie Salpetriere, Paris, France.
[Link to Abstract]


NOVEMBER

Intra-Arterial Infusion of 5-Fluorouracil, Leucovorin, Epirubicin and Carboplatin (FLEC Regimen) in Unresectable Pancreatic Cancer: Results of a Ten-Year Experience.
Mambrini A, Sanguinetti F, Pacetti P, Caudana R, Iacono C, Guglielmi A, Guadagni S, Del Freo A, Fiorentini G, Cantore M.
In Vivo. 2006 Nov-Dec;20(6A):751-5. Massa-Carrara City Hospital, Italy.
[Link to Abstract]

Potentiation of the Effect of Erlotinib by Genistein in Pancreatic Cancer: The Role of Akt and Nuclear Factor-Kappab.
El-Rayes BF, Ali S, Ali IF, Philip PA, Abbruzzese J, Sarkar FH.
Cancer Res. 2006 Nov 1;66(21):10553-9. Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
[Link to Abstract]

Radiofrequency Ablation Combined with Palliative Surgery May Prolong Survival of Patients with Advanced Cancer of The Pancreas.
Spiliotis JD, Datsis AC, Michalopoulos NV, Kekelos SP, Vaxevanidou A, Rogdakis AG, Christopoulou AN.
Langenbecks Arch Surg. 2007 Jan;392(1):55-60. Epub 2006 Nov 7. Hatzikostas General Hospital, Messologi, Greece.
[Link to Abstract]

Rapamycin Synergizes with the Epidermal Growth Factor Receptor Inhibitor Erlotinib in Non-Small-Cell Lung, Pancreatic, Colon, and Breast Tumors.
Buck E, Eyzaguirre A, Brown E, Petti F, McCormack S, Haley JD, Iwata KK, Gibson NW, Griffin G.
Mol Cancer Ther. 2006 Nov;5(11):2676-84. OSI Pharmaceuticals, Farmingdale, New York.
[Link to Abstract]


OCTOBER

Clinical Results on Intra-Arterial Adjuvant Chemotherapy for Prevention of Liver Metastasis Following Curative Resection of Pancreatic Cancer.
Hayashibe A, Kameyama M, Shinbo M, Makimoto S.
Ann Surg Oncol. 2007 Jan;14(1):190-4. Epub 2006 Oct 26. Bell Land General Hospital, Sakai City, Osaka, Japan.
[Link to Abstract]

Pancreatic Resection for M1 Pancreatic Ductal Adenocarcinoma.
Shrikhande SV, Kleeff J, Reiser C, Weitz J, Hinz U, Esposito I, Schmidt J, Friess H, Buchler MW.
Ann Surg Oncol. 2007 Jan;14(1):118-27.Epub 2006 Oct 25. Tata Memorial Hospital, Mumbai, India.
[Link to Abstract]

RP101 Improves the Efficacy of Chemotherapy in Pancreas Carcinoma Cell Lines and Pancreatic Cancer Patients.
Fahrig R, Quietzsch D, Heinrich JC, Heinemann V, Boeck S, Schmid RM, Praha C, Liebert A, Sonntag D, Krupitza G, Hanel M.
Anticancer Drugs. 2006 Oct;17(9):1045-56. RESprotect, Dresden Germany.
[Link to Abstract]

Telomerase Peptide Vaccination of Patients with Non-Resectable Pancreatic Cancer: A Dose Escalating Phase I/II Study.
Bernhardt SL, Gjertsen MK, Trachsel S, Moller M, Eriksen JA, Meo M, Buanes T, Gaudernack G.
Br J Cancer. 2006 Dec 4;95(11):1474-82. Epub 2006 Oct 24. Ulleval University Hospital, Oslo, Norway.
[Link to Abstract]


SEPTEMBER

Effects of Low-Dose Warfarin and Regional Chemotherapy on Survival in Patients with Pancreatic Carcinoma.
Nakchbandi W, Muller H, Singer MV, Lohr M, Nakchbandi IA.
Scand J Gastroenterol. 2006 Sep;41(9):1095-104. Carl von Hess Hospital, Hammelburg, Germany.
[Link to Abstract]

Pancreatic Resections after Chemoradiotherapy for Locally Advanced Ductal Adenocarcinoma: Analysis of Perioperative Outcome and Survival.
Massucco P, Capussotti L, Magnino A, Sperti E, Gatti M, Muratore A, Sgotto E, Gabriele P, Aglietta M.
Ann Surg Oncol. 2006 Sep;13(9):1201-8. Institute for Research and Cure of Cancer, Candiolo, Italy.
[Link to Abstract]

Postoperative Morbidity and Long-Term Survival after Pancreaticoduodenectomy with Superior Mesenterico-Portal Vein Resection.
Riediger H, Makowiec F, Fischer E, Adam U, Hopt UT.
J Gastrointest Surg. 2006 Sep-Oct;10(8):1106-15. University of Freiburg, Germany.
[Link to Abstract]

Staging of Pancreatic Cancer with Multidetector CT in the Setting of Preoperative Chemoradiation Therapy.
Tamm EP, Loyer EM, Faria S, Raut CP, Evans DB, Wolff RA, Crane CH, Dubrow RA, Charnsangavej C.
Abdom Imaging. 2006 Sep 12; [Epub]. University of Texas / M.D. Anderson Cancer Center, Houston, Texas.
[Link to Abstract]


AUGUST

Antitumor Effect of Trastuzumab for Pancreatic Cancer with High HER-2 Expression and Enhancement of Effect by Combined Therapy with Gemcitabine.
Kimura K, Sawada T, Komatsu M, Inoue M, Muguruma K, Nishihara T, Yamashita Y, Yamada N, Ohira M, Hirakawa K.
Clin Cancer Res. 2006 Aug 15;12(16):4925-32. Osaka City University Graduate School of Medicine, Japan.
[Link to Abstract]

Are Capecitabine and Oxaliplatin (XELOX) Suitable Treatments for Progressing Low-Grade and High-Grade Neuroendocrine Tumours?
Bajetta E, Catena L, Procopio G, De Dosso S, Bichisao E, Ferrari L, Martinetti A, Platania M, Verzoni E, Formisano B, Bajetta R.
Cancer Chemother Pharmacol. 2006 Aug 26; [Epub]. Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
[Link to Abstract]

Randomized Phase III Trial of Gemcitabine Plus Cisplatin Compared with Gemcitabine Alone in Advanced Pancreatic Cancer.
Heinemann V, Quietzsch D, Gieseler F, Gonnermann M, Schonekas H, Rost A, Neuhaus H, Haag C, Clemens M, Heinrich B, Vehling-Kaiser U, Fuchs M, Fleckenstein D, Gesierich W, Uthgenannt D, Einsele H, Holstege A, Hinke A, Schalhorn A, Wilkowski R.
J Clin Oncol. 2006 Aug 20;24(24):3946-52. Klinikum Grosshadern, Munich, Germany.
[Link to Abstract]

Resection of Pancreatic Neuroendocrine Tumors: Results of 70 Cases.
Kazanjian KK, Reber HA, Hines OJ.
Arch Surg. 2006 Aug;141(8):765-9; discussion 769-70. University of California, Los Angeles.
[Link to Abstract]


JULY

Chemoradiotherapy with Gemcitabine and Continuous 5-FU in Patients with Primary Inoperable Pancreatic Cancer.
Wilkowski R, Thoma M, Bruns C, Wagner A, Heinemann V.
JOP. 2006 Jul 10;7(4):349-60. LMU University Hospital Grosshadern, Munich, Germany.
[Link to Abstract]

Interferon-Alpha + Cisplatin + 5-FU Therapy for Gemcitabine-Refractory Unresectable and Recurrent Pancreatic Cancer.
Ueda M, Endo I, Fujii Y, Miura Y, Kubota T, Tanaka K, Ichikawa Y, Togo S, Shimada H.
Gan To Kagaku Ryoho. 2006 Jul;33(7):937-40. Yokohama City University Graduate School of Medicine, Japan.
[Link to Abstract]

Phase I/II Trial of Hyperfractionated Accelerated Chemoradiotherapy for Unresectable Advanced Pancreatic Cancer.
Tsujie M, Nakamori S, Tanaka E, Nagano H, Umeshita K, Dono K, Sakon M, Inoue T, Inoue T, Monden M.
Jpn J Clin Oncol. 2006 Aug;36(8):504-10. Epub 2006 Jul 19. Osaka National Hospital, Japan.
[Link to Abstract]

A Phase II Study of Weekly Irinotecan as First-Line Therapy for Patients with Metastatic Pancreatic Cancer.
Ueno H, Okusaka T, Funakoshi A, Ishii H, Yamao K, Ishikawa O, Ohkawa S, Saitoh S.
Cancer Chemother Pharmacol. 2006 Jul 20;[Epub]. National Cancer Center Hospital, Tokyo, Japan.
[Link to Abstract]


JUNE

Combination Chemotherapy with Gemcitabine and S-1 for Advanced Pancreatic Cancer.
Nakamura K, Yamaguchi T, Sudo K, Ishihara T, Saisho H.
Gan To Kagaku Ryoho. 2006 Jun;33 Suppl 1:219-23. Shimizu Kousei Hospital, Shizuoka, Japan.
[Link to Abstract]

Dose-Intense PEFG (Cisplatin, Epirubicin, 5-Fluorouracil, Gemcitabine) in Advanced Pancreatic Adenocarcinoma.
Reni M, Cereda S, Bonetto E, Vigano MG, Passoni P, Zerbi A, Balzano G, Nicoletti R, Staudacher C, Di Carlo V.
Cancer Chemother Pharmacol. 2006 Jun 29; [Epub]. San Raffaele Scientific Institute, Milan, Italy.
[Link to Abstract]

Phase I and Pharmacokinetic Study of S-1 Administered for 14 Days in a 21-Day Cycle in Patients with Advanced Upper Gastrointestinal Cancer.
Zhu AX, Clark JW, Ryan DP, Meyerhardt JA, Enzinger PC, Earle CC, Fuchs CS, Regan E, Anbe H, Houghton M, Zhang J, Urrea P, Kulke MH.
Cancer Chemother Pharmacol. 2006 Jun 20; [Epub]. Massachusetts General Hospital, Boston.
[Link to Abstract]

S-1 Monotherapy for Pancreatic Cancer.
Okusaka T, Ueno H, Ikeda M, Morizane C.
Gan To Kagaku Ryoho. 2006 Jun;33 Suppl 1:207-12. National Cancer Center Hospital, Tokyo, Japan.
[Link to Abstract]


MAY

Liposomal Cisplatin Combined with Gemcitabine in Pretreated Advanced Pancreatic Cancer Patients: A Phase I-II Study.
Stathopoulos GP, Boulikas T, Vougiouka M, Rigatos SK, Stathopoulos JG.
Oncol Rep. 2006 May;15(5):1201-4. Errikos Dunant Hospital and Medical School of Athens, Greece.
[Link to Abstract]

Phase I Study of The Humanised Anti-EGFR Monoclonal Antibody Matuzumab (EMD 72000) Combined with Gemcitabine in Advanced Pancreatic Cancer.
Graeven U, Kremer B, Sudhoff T, Killing B, Rojo F, Weber D, Tillner J, Unal C, Schmiegel W. Br J Cancer. 2006 May 8;94(9):1293-9. Ruhr University Bochum, and University Hospital of Schleswig-Holstein, Kiel, Germany.
[Link to Abstract]

A Phase II Trial of Epothilone B Analogue BMS-247550 (NSC #710428) Ixabepilone, in Patients with Advanced Pancreas Cancer: A Southwest Oncology Group Study.
Whitehead RP, McCoy S, Rivkin SE, Gross HM, Conrad ME, Doolittle GC, Wolff RA, Goodwin JW, Dakhil SR, Abbruzzese JL.
Invest New Drugs. 2006 May 11;[Epub]. University of Texas Medical Branch, Galveston, Texas.
[Link to Abstract]

Unfavourable Prognosis Associated with K-Ras Gene Mutation in Pancreatic Cancer Surgical Margins
Kim J, Reber HA, Dry SM, Elashoff D, Chen SL, Umetani N, Kitago M, Hines OJ, Kazanjian KK, Hiramatsu SH, Bilchik AJ, Yong S, Shoup M, Hoon DS.
Gut. 2006 May 8;[Epub]. John Wayne Cancer Institute, Santa Monica, California.
[Link to Abstract]


APRIL

Adjuvant Intra-Arterial 5-Fluoruracil, Leucovorin, Epirubicin and Carboplatin With or Without Systemic Gemcitabine After Curative Resection for Pancreatic Adenocarcinoma.
Cantore M, Serio G, Pederzoli P, Mambrini A, Iacono C, Pulica C, Capelli P, Lombardi M, Torri T, Pacetti P, Pagani M, Fiorentini G.
Cancer Chemother Pharmacol. 2006 Apr 22; Epub. General City Hospital, Massa Carrara, Italy.
[Link to Abstract]

The Argument for Pre-operative Chemoradiation for Localized, Radiographically Resectable Pancreatic Cancer.
Crane CH, Varadhachary G, Wolff RA, Pisters PW, Evans DB.
Best Pract Res Clin Gastroenterol. 2006 Apr;20(2):365-82. University of Texas / M.D. Anderson Cancer Center, Houston, Texas.
[Link to Abstract]

Maintenance Chemotherapy After Chemoradiation Improves Survival of Patients with Locally Advanced Pancreatic Carcinoma: A Retrospective Analysis of Prospectively Recruited Patients.
Brunner TB, Tinkl D, Grabenbauer GG, Meyer T, Brueckl WM, Sauer R.
Strahlenther Onkol. 2006 Apr;182(4):210-5. Friedrich Alexander University of Erlangen-Nuremberg, Germany.
[Link to Abstract]

Venous Resection in Pancreatic Cancer Surgery.
Tseng JF, Tamm EP, Lee JE, Pisters PW, Evans DB.
Best Pract Res Clin Gastroenterol. 2006 Apr;20(2):349-64. University of Massachusetts Medical School, Worcester, Massachusetts.
[Link to Abstract]

MARCH

The Long-Term Survival of a Patient with Pancreatic Cancer with Metastases to the Liver after Treatment with the Intravenous alpha-lipoic acid/low-dose naltrexone Protocol.
Berkson BM, Rubin DM, Berkson AJ.
Integr Cancer Ther. 2006 Mar;5(1):83-9. Integrative Medical Center of New Mexico and New Mexico State University, Las Cruces, New Mexico.
[Link to Abstract]

A Phase I Study of Oral Uracil-Tegafur Prior to Weekly Intravenous Gemcitabine in Patients with Advanced Pancreatic Cancer.
Tanno S, Nakano Y, Osanai M, Koizumi K, Izawa T, Habiro A, Mizukami Y, Yanagawa N, Fujii T, Okumura T, Kohgo Y.
Chemotherapy. 2006;52(2):98-102. Epub 2006 Mar 27. Asahikawa Medical College, Asahikawa, Japan.
[Link to Abstract]

Phase I Trial Evaluating the Safety of Bevacizumab with Concurrent Radiotherapy and Capecitabine in Locally Advanced Pancreatic Cancer.
Crane CH, Ellis LM, Abbruzzese JL, Amos C, Xiong HQ, Ho L, Evans DB, Tamm EP, Ng C, Pisters PW, Charnsangavej C, Delclos ME, O'Reilly M, Lee JE, Wolff RA.
J Clin Oncol. 2006 Mar 1;24(7):1145-51. University of Texas / M.D. Anderson Cancer Center, Houston, Texas.
[Link to Abstract]

Raltitrexed-Eloxatin Salvage Chemotherapy in Gemcitabine-Resistant Metastatic Pancreatic Cancer.
Reni M, Pasetto L, Aprile G, Cordio S, Bonetto E, Dell'Oro S, Passoni P, Piemonti L, Fugazza C, Luppi G, Milandri C, Nicoletti R, Zerbi A, Balzano G, Di Carlo V, Brandes AA.
Br J Cancer. 2006 Mar 27;94(6):785-91. San Raffaele Scientific Institute., Milan, Italy.
[Link to Abstract]


FEBRUARY

Evaluation of the Efficacy of Combined Continuous Arterial Infusion and Systemic Chemotherapy for the Treatment of Advanced Pancreatic Carcinoma.
Ikeda O, Kusunoki S, Kudoh K, Takamori H, Tsuji T, Kanemitsu K, Yamashita Y.
Cardiovasc Intervent Radiol. 2006 May-Jun;29(3):362-70. Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Japan.
[Link to Abstract]

Immunomodulatory Impact of Interferon-Alpha in Combination with Chemoradiation of Pancreatic Adenocarcinoma (Capri).
Schmidt J, Patrut EM, Ma J, Jager D, Knaebel HP, Buchler MW, Marten A.
Cancer Immunol Immunother. 2006 Epub Feb 17, 2006. University of Heidelberg, Germany.
[Link to Abstract]

Multicenter Phase-I/II Study Using a Combination of Gemcitabine and Docetaxel in Metastasized and Unresectable, Locally Advanced Pancreatic Carcinoma.
Ridwelski K, Fahlke J, Kuhn R, Hribaschek A, Kettner E, Greiner C, Florschuetz A, Manger T, Wilhelm G, Klein H, Hahnfeld S, Lippert H, Meyer F.
Eur J Surg Oncol. 2006 Apr;32(3):297-302. Epub 2006 Jan 18. Otto von Guericke University, Magdeburg, Germany.
[Link to Abstract]

Phase II Study 0f Temozolomide and Thalidomide in Patients with Metastatic Neuroendocrine Tumors.
Kulke MH, Stuart K, Enzinger PC, Ryan DP, Clark JW, Muzikansky A, Vincitore M, Michelini A, Fuchs CS.
J Clin Oncol. 2006 Jan 20;24(3):401-6. Dana-Farber Cancer Institute, Boston, Massachusetts.
[Link to Abstract]


JANUARY

Comparison of Standard-Dose and Low-Dose Gemcitabine Regimens in Pancreatic Adenocarcinoma Patients: A Prospective Randomized Trial.
Sakamoto H, Kitano M, Suetomi Y, Takeyama Y, Ohyanagi H, Nakai T, Yasuda C, Kudo M.
J Gastroenterol. 2006 Jan;41(1):70-6. Kinki University School of Medicine, Osaka-Sayama, Japan.
[Link to Abstract]

Gemcitabine and Oxaliplatin (GEMOX) in Gemcitabine Refractory Advanced Pancreatic Adenocarcinoma: A Phase II Study.
Demols A, Peeters M, Polus M, Marechal R, Gay F, Monsaert E, Hendlisz A, Van Laethem JL.
Br J Cancer. 2006 Feb 27;94(4):481-5 (Epub 2006 Jan24). Erasme University Hospital, Brussels, Belgium.
[Link to Abstract]

A Multi-Institutional Phase II Trial of Preoperative Full-Dose Gemcitabine and Concurrent Radiation for Patients with Potentially Resectable Pancreatic Carcinoma.
Talamonti MS, Small W Jr, Mulcahy MF, Wayne JD, Attaluri V, Colletti LM, Zalupski MM, Hoffman JP, Freedman GM, Kinsella TJ, Philip PA, McGinn CJ.
Ann Surg Oncol. 2006 Feb;13(2):150-8 (Epub 2006 Jan 19). Feinberg School of Medicine, Northwestern University, Chicago.
[Link to Abstract]

Phase II Study of Fixed Dose Rate Gemcitabine with Cisplatin for Metastatic Adenocarcinoma of The Pancreas.
Ko AH, Dito E, Schillinger B, Venook AP, Bergsland EK, Tempero MA.
J Clin Oncol. 2006 Jan 20;24(3):379-85. University of California at San Francisco Comprehensive Cancer Center, San Francisco.
[Link to Abstract]


2005

DECEMBER

Brief Communication: A New Combination in the Treatment of Advanced Pancreatic Cancer.
Moore MJ.
Semin Oncol. 2005 Dec;32(6 Suppl 8):5-6. Princess Margaret Hospital, Toronto, Canada.
[Link to Abstract]

Chemoradiotherapy in Patients with Pancreatic Carcinoma: Phase-I Study with a Fixed Radiation Dose and Escalating Doses of Weekly Gemcitabine.
Oya N, Shibuya K, Sakamoto T, Mizowaki T, Doi R, Fujimoto K, Imamura M, Nagata Y, Hiraoka M.
Pancreatology. 2005 Dec 1;6(1-2):109-116. Graduate School of Medicine, Kyoto University, Japan.
[Link to Abstract]

Docetaxel Plus Gemcitabine or Docetaxel Plus Cisplatin in Advanced Pancreatic Carcinoma: Randomized Phase II Study 40984 of The European Organisation for Research and Treatment of Cancer Gastrointestinal Group.
Lutz MP, Cutsem EV, Wagener T, Van Laethem JL, Vanhoefer U, Wils JA, Gamelin E, Koehne CH, Arnaud JP, Mitry E, Husseini F, Reichardt P, El-Serafi M, Etienne PL, Lingenfelser T, Praet M, Genicot B, Debois M, Nordlinger B, Ducreux MP.
J Clin Oncol. 2005 Dec 20;23(36):9250-6. University of Ulm, Germany
[Link to Abstract]

Erlotinib and Chemoradiation Followed by Maintenance Erlotinib for Locally Advanced Pancreatic Cancer: A Phase I Study.
Iannitti D, Dipetrillo T, Akerman P, Barnett JM, Maia-Acuna C, Cruff D, Miner T, Martel D, Cioffi W, Remis M, Kennedy T, Safran H.
Am J Clin Oncol. 2005 Dec;28(6):570-5. Brown University Oncology Group, Providence, Rhode Island.
[Link to Abstract]


NOVEMBER

Complete Remission of Liver Metastasis of Pancreatic Cancer Under Vaccination with a HLA-A2 Restricted Peptide Derived from the Universal Tumor Antigen Survivin.
Wobser M, Keikavoussi P, Kunzmann V, Weininger M, Andersen MH, Becker JC.
Cancer Immunol Immunother. 2005 Nov 29;1-5. University of Wuerzburg, Germany.
[Link to Abstract]

Docetaxel/Gemcitabine Followed by Gemcitabine and External Beam Radiotherapy in Patients with Pancreatic Adenocarcinoma.
Pipas JM, Barth RJ Jr, Zaki B, Tsapakos MJ, Suriawinata AA, Bettmann MA, Cates JM, Ripple GH, Sutton JE, Gordon SR, McDonnell CE, Perez RP, Redfield N, Meyer LP, Marshall JF, Cole BF, Colacchio TA.
Ann Surg Oncol. 2005 Dec;12(12):995-1004. Epub 2005 Nov 1. Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center, Lebanon, New Hampshire.
[Link to Abstract]


Phase II Trial of Bevacizumab Plus Gemcitabine in Patients with Advanced Pancreatic Cancer.
Kindler HL, Friberg G, Singh DA, Locker G, Nattam S, Kozloff M, Taber DA, Karrison T, Dachman A, Stadler WM, Vokes EE.
J Clin Oncol. 2005 Nov 1;23(31):8033-40. University of Chicago Medical Center, Illinois.
[Link to Abstract]

Phase III Randomised Comparison of Gemcitabine (GEM) Versus Gemcitabine Plus Capecitabine (GEM-CAP) in Patients with Advanced Pancreatic Cancer.
Chua YJ, Cunningham D, et al.
European Cancer Conference (ECCO 13), presentation/abstract PS11, Paris, France, 2005 November 2. Royal Marsden Hospital, London, England.
[Link to Abstract]


OCTOBER 

Borderline Resectable Pancreatic Cancer.
Varadhachary GR, Tamm EP, Crane C, Evans DB, Wolff RA
Curr Treat Options Gastroenterol. 2005 Oct;8(5):377-84. M.D. Anderson Cancer Center, Houston, Texas.
[Link to Abstract]

Combination Therapy for Advanced Pancreatic Cancer Using Herceptin Plus Chemotherapy.
Buchler P, Reber HA, Eibl G, Roth MA, Buchler MW, Friess H, Isacoff WH, Hines OJ.
Int J Oncol. 2005 Oct;27(4):1125-30. University of Heidelberg, Germany.
[Link to Abstract]

Combined Systemic and Intraarterial Chemotherapy with Gemcitabine and Concomitant External-Beam Radiotherapy in Patients with Liver Metastasis from Pancreatic Cancer - A Report of Two Cases.
Matsugu Y, Tanaka T, Kagawa N, Nakahara H, Ishimoto T, Fukuda Y.
Gan To Kagaku Ryoho. 2005 Oct;32(10):1489-92. Hiroshima Prefectural Hospital, Japan.
[Link to Abstract]

Phase II Study to Assess the Efficacy of Conventionally Fractionated Radiotherapy Followed By a Stereotactic Radiosurgery Boost in Patients with Locally Advanced Pancreatic Cancer.
Koong AC, Christofferson E, Le QT, Goodman KA, Ho A, Kuo T, Ford JM, Fisher GA, Greco R, Norton J, Yang GP.
Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):320-3. Stanford University School of Medicine, Stanford, California.
[Link to Abstract]


SEPTEMBER

Bevacizumab as Treatment for Chemotherapy-Resistant Pancreatic Cancer.
Bruckner HW, Hrehorovich VR, Sawhney HS.
Anticancer Res. 2005 Sep-Oct;25(5):3637-9. Lutheran Medical Center, Brooklyn, New York.
[Link to Abstract]

Fixed Dose-Rate Gemcitabine Infusion as First-Line Treatment for Advanced-Stage Carcinoma of The Pancreas and Biliary Tree.
Gelibter A, Malaguti P, Di Cosimo S, Bria E, Ruggeri EM, Carlini P, Carboni F, Ettorre GM, Pellicciotta M, Giannarelli D, Terzoli E, Cognetti F, Milella M.
Cancer. 2005 Sep 15;104(6):1237-45. Regina Elena National Cancer Institute, Rome, Italy.
[Link to Abstract]

Gemcitabine Plus Celecoxib (GECO) in Advanced Pancreatic Cancer: A Phase II Trial.
Ferrari V, Valcamonico F, Amoroso V, Simoncini E, Vassalli L, Marpicati P, Rangoni G, Grisanti S, Tiberio GA, Nodari F, Strina C, Marini G.
Cancer Chemother Pharmacol. 2005 Sep 3;:1-6. U.O. Oncologia Medica, Beretta Foundation, Brescia, Italy.
[Link to Abstract]

Surgical Resection After Radiochemotherapy in Patients with Unresectable Adenocarcinoma of the Pancreas.
Sa Cunha A, Rault A, Laurent C, Adhoute X, Vendrely V, Bellannee G, Brunet R, Collet D, Masson B.
J Am Coll Surg. 2005 Sep;201(3):359-65. Groupe Hospitalier Sud, CHU Bordeaux, Pessac, France.
[Link to Abstract]


AUGUST

Adjuvant Gemcitabine and Concurrent Continuous Radiation (45 Gy) for Resected Pancreatic Head Carcinoma: A Multicenter Belgian Phase II Study.
Demols A, Peeters M, Polus M, Honore P, Boterberg T, Gay F, Closon MT, Van Houtte P, Closset J, Van Laethem JL.
Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1351-6. Erasme University Hospital, Brussels, Belgium.
[Link to Abstract]

Phase II Study on Low Dose Gemcitabine Plus Oral Chemotherapy with Uracil-Tegafur and Cyclophosphamide in Combination with Radiotherapy Against Recurrent and Advanced Pancreatic Cancer.
Nio Y, Hashimoto K, Yano S, Itakura M, Koike M, Yamaguchi K, Endo S, Tsuji M, Higami T, Maruyama R.
Oncol Rep. 2005 Aug;14(2):401-8. Shimane University School of Medicine, Japan.
[Link to Abstract]

Second-Line Treatment with Oxaliplatin, Leucovorin and 5-Fluorouracil in Gemcitabine-Pretreated Advanced Pancreatic Cancer: A Phase II Study.
Tsavaris N, Kosmas C, Skopelitis H, Gouveris P, Kopteridis P, Loukeris D, Sigala F, Zorbala-Sypsa A, Felekouras E, Papalambros E.
Invest New Drugs. 2005 Aug;23(4):369-75. Metaxa Memorial Cancer Hospital, Piraeus, Greece.
[Link to Abstract]

Toxicities and Effects of Involved-Field Irradiation with Concurrent Cisplatin for Unresectable Carcinoma of The Pancreas.
Kawakami H, Uno T, Isobe K, Ueno N, Aruga T, Sudo K, Yamaguchi T, Saisho H, Kawata T, Ito H.
Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1357-62. Chiba University Graduate School of Medicine, Japan.
[Link to Abstract]


JULY

An Early Phase II Study of S-1 in Patients with Metastatic Pancreatic Cancer.
Ueno H, Okusaka T, Ikeda M, Takezako Y, Morizane C.
Oncology. 2005;68(2-3):171-8. 2005 Jul 4. National Cancer Center Hospital, Tokyo, Japan.
[Link to Abstract]

Feasibility of US-Guided High-Intensity Focused Ultrasound Treatment in Patients with Advanced Pancreatic Cancer: Initial Experience.
Wu F, Wang ZB, Zhu H, Chen WZ, Zou JZ, Bai J, Li KQ, Jin CB, Xie FL, Su HB.
Radiology. 2005 Sep;236(3):1034-40. 2005 Jul 29. Chongqing University of Medical Sciences, Chongqing, China
[Link to Abstract]

Phase II Trial of Primary Radiation Therapy and Concurrent Chemotherapy for Patients with Locally Advanced Pancreatic Cancer.
Magnino A, Gatti M, Massucco P, Sperti E, Faggiuolo R, Regge D, Capussotti L, Gabriele P, Aglietta M.
Oncology. 2005;68(4-6):493-9. 2005 Jul 13. Institute for Research and Cure of Cancer, Candiolo, Italy.
[Link to Abstract]

Serum CA19-9 Response as a Surrogate for Clinical Outcome in Patients Receiving Fixed-Dose Rate Gemcitabine for Advanced Pancreatic Cancer.
Ko AH, Hwang J, Venook AP, Abbruzzese JL, Bergsland EK, Tempero MA.
Br J Cancer. 2005 Jul 25;93(2):195-9. University of California at San Francisco Comprehensive Cancer Center.
[Link to Abstract]


JUNE

Gemcitabine Versus Cisplatin, Epirubicin, Fluorouracil, and Gemcitabine in Advanced Pancreatic Cancer: A Randomised Controlled Multicentre Phase III Trial.
Reni M, Cordio S, Milandri C, Passoni P, Bonetto E, Oliani C, Luppi G, Nicoletti R, Galli L, Bordonaro R, Passardi A, Zerbi A, Balzano G, Aldrighetti L, Staudacher C, Villa E, Di Carlo V.
Lancet Oncol. 2005 Jun;6(6):369-76. S Raffaele H Scientific Institute, Milan, Italy.
[Link to Abstract]

A Novel Anti-Pancreatic Cancer Agent, LY293111.
Ding XZ, Talamonti MS, Bell RH Jr, Adrian TE.
Anticancer Drugs. 2005 Jun;16(5):467-73. Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
[Link to Abstract]

Phase I Trial of Oral S-1 Combined with Gemcitabine in Metastatic Pancreatic Cancer.
Nakamura K, Yamaguchi T, Ishihara T, Kobayashi A, Tadenuma H, Sudo K, Kato H, Saisho H.
Br J Cancer. 2005 Jun 20;92(12):2134-9. Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan.
[Link to Abstract]

A Phase II Study of Alternating Cycles of Split Course Radiation Therapy and Gemcitabine Chemotherapy for Inoperable Pancreatic or Biliary Tract Carcinoma.
Lin LL, Picus J, Drebin JA, Linehan DC, Solis J, Strasberg SM, Tan B, Thorstad WL, Myerson R.
Am J Clin Oncol. 2005 Jun;28(3):234-41. Washington University School of Medicine, St. Louis, Missouri.
[Link to Abstract]


MAY

Clinical Experience with Chronomodulated Infusional 5-Fluorouracil Chemoradiotherapy for Pancreatic Adenocarcinoma.
Keene KS, Rich TA, Penberthy DR, Shepard RC, Adams R, Jones RS.
Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):97-103. University of Virginia Health Science Center, Charlottesville, Virginia.
[Link to Abstract]

Epidermal Growth Factor Receptor and Activated Epidermal Growth Factor Receptor Expression in Gastrointestinal Carcinoids and Pancreatic Endocrine Carcinomas.
Papouchado B, Erickson LA, Rohlinger AL, Hobday TJ, Erlichman C, Ames MM, Lloyd RV.
Mod Pathol. 2005 May 6 [Epub]. Mayo Clinic College of Medicine, Rochester, Minnesota.
[Link to Abstract]

Neuroendocrine Hepatic Metastases: Does Aggressive Management Improve Survival?
Touzios JG, Kiely JM, Pitt SC, Rilling WS, Quebbeman EJ, Wilson SD, Pitt HA.
Ann Surg. 2005 May;241(5):776-83; discussion 783-5. Medical College of Wisconsin, Milwaukee, Wisconsin.
[Link to Abstract]

A Phase II Study of Combination Chemotherapy with Gemcitabine, 5-Fluorouracil, and Cisplatin for Advanced Pancreatic Cancer.
Choi SB, Lee HY, Yuh YJ, Kim SR.
Korean J Gastroenterol. 2005 May;45(5):348-53. Inje University Collage of Medicine, Sanggye Paik Hospital, Seoul, Korea.
[Link to Abstract]


APRIL

5-Fluorouracil Intra-Arterial Infusion Combined with Systemic Gemcitabine for Unresectable Pancreatic Cancer.
Takamori H, Kanemitsu K, Tsuji T, Tanaka H, Chikamoto A, Nakahara O, Hiraoka T, Ikeda O, Kudo K, Imuta M, Yamashita Y.
Pancreas. 2005 Apr;30(3):223-6. Graduate School of Medical Sciences, Kumamoto University, Japan.
[Link to Abstract]

Meta-Analysis of Randomised Adjuvant Therapy Trials for Pancreatic Cancer.
Stocken DD, Buchler MW, Dervenis C, Bassi C, Jeekel H, Klinkenbijl JH, Bakkevold KE, Takada T, Amano H, Neoptolemos JP; Pancreatic Cancer Meta-analysis Group.
Br J Cancer. 2005 Apr 25;92(8):1372-81. University of Birmingham, UK.
[Link to Abstract]

Parthenolide and Sulindac Cooperate to Mediate Growth Suppression and Inhibit the Nuclear Factor-Kappa B Pathway in Pancreatic Carcinoma Cells.
Yip-Schneider MT, Nakshatri H, Sweeney CJ, Marshall MS, Wiebke EA, Schmidt CM.
Mol Cancer Ther. 2005 Apr;4(4):587-94. Indiana University School of Medicine, Indianapolis, Indiana.
[Link to Abstract]

Thalidomide in the Treatment of Cancer Cachexia: A Randomised Placebo Controlled Trial.
Gordon JN, Trebble TM, Ellis RD, Duncan HD, Johns T, Goggin PM.
Gut. 2005 Apr;54(4):540-5. Southampton General Hospital, England.
[Link to Abstract]


MARCH

Increased Preoperative Platelet Count is Associated with Decreased Survival After Resection for Adenocarcinoma of The Pancreas.
Brown KM, Domin C, Aranha GV, Yong S, Shoup M.
Am J Surg. 2005 Mar;189(3):278-82. Loyola University Medical Center, Maywood, Illinois
[Link to Abstract]

Intra-Arterial Bolus Octreotide Administration During Whipple Procedure in Patients with Fragile Pancreas: A Novel Technique for Safer Pancreaticojejunostomy.
Konstadoulakis MM, Filippakis GM, Lagoudianakis E, Antonakis PT, Dervenis C, Bramis J.
J Surg Oncol. 2005 Mar 15;89(4):268-72. Hippocration Hospital, Athens Medical School, Greece.
[Link to Abstract]

Randomized Clinical Trial of Pylorus-Preserving Duodenopancreatectomy Versus Classical Whipple Resection -Long Term Results.
Seiler CA, Wagner M, Bachmann T, Redaelli CA, Schmied B, Uhl W, Friess H, Buchler MW.
Br J Surg. 2005 May;92(5):547-56. University of Berne, Inselspital, Switzerland.
[Link to Abstract]

Synergistic Effects of Interferon-Alpha in Combination with Chemoradiation on Human Pancreatic Adenocarcinoma.
Ma JH, Patrut E, Schmidt J, Knaebel HP, Buchler MW, Marten A.
World J Gastroenterol. 2005 Mar 14;11(10):1521-8. University of Heidelberg, Germany.
[Link to Abstract]


FEBRUARY

Growth Inhibition of Human Pancreatic Cancer Cells by Human Interferon-Beta Gene Combined with Gemcitabine.
Endou M, Mizuno M, Nagata T, Tsukada K, Nakahara N, Tsuno T, Osawa H, Kuno T, Fujita M, Hatano M, Yoshida J.
Int J Mol Med. 2005 Feb;15(2):277-83. Toyama Medical and Pharmaceutical University, Nagoya, Japan.
[Link to Abstract]

Growth Stimulation of COX-2-Negative Pancreatic Cancer by a Selective COX-2 Inhibitor.
Eibl G, Takata Y, Boros LG, Liu J, Okada Y, Reber HA, Hines OJ.
Cancer Res. 2005 Feb 1;65(3):982-90. David Geffen School of Medicine at University of California-Los Angeles.
[Link to Abstract]

A Pharmacological Study of Celecoxib and Gemcitabine in Patients with Advanced Pancreatic Cancer.
Xiong HQ, Plunkett W, Wolff R, Du M, Lenzi R, Abbruzzese JL.
Cancer Chemother Pharmacol. 2005 Feb 22. University of Texas / MD Anderson Cancer Center, Houston, Texas.
[Link to Abstract]

Photodynamic Therapy for Pancreatic and Biliary Tract Carcinoma.
Ayaru L, Bown SG, Pereira SP.
Int J Gastrointest Cancer. 2005;35(1):1-14. Royal Free & University College London Medical School, England.
[Link to Abstract]


JANUARY

Homozygous Deletion of the MTAP Gene in Invasive Adenocarcinoma of the Pancreas and in Periampullary Cancer: A Potential New Target for Therapy.
Hustinx SR, Hruban RH, Leoni LM, Iacobuzio-Donahue C, Cameron JL, Yeo CJ, Brown PN, Argani P, Asfaq R, Fukushima N, Goggins M, Kern SE, Maitra A.
Cancer Biol Ther. 2005 Jan 15;4(1). Johns Hopkins Medical Institutions, Baltimore, Maryland; Academic Medical Center, Amsterdam, Netherlands.
[Link to Abstract]

Phase I and Pharmacokinetic Study of DE-310 in Patients with Advanced Solid Tumors.
Soepenberg O, de Jonge MJ, Sparreboom A, de Bruin P, Eskens FA, de Heus G, Wanders J, Cheverton P, Ducharme MP, Verweij J.
Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):703-11. Erasmus University Medical Center, Rotterdam, Netherlands.
[Link to Abstract]

Quality of Life After Curative or Palliative Surgical Treatment of Pancreatic and Periampullary Carcinoma.
Nieveen van Dijkum EJ, Kuhlmann KF, Terwee CB, Obertop H, de Haes JC, Gouma DJ.
Br J Surg. 2005 Jan 25. Academic Medical Centre, University of Amsterdam, Netherlands.
[Link to Abstract]

Raltitrexed Plus Gemcitabine (TOMGEM) in Advanced Pancreatic Cancer. Results of a Belgian Multicentre Phase II Study.
Van Laethem JL, Van Maele P, Verslype C, Polus M, Demols A, Houbiers G, Caenepeel P, Leleux A, Vermaut RR, Van Cutsem E, Peeters M.
Oncology. 2004;67(5-6):338-43. Erasme University Hospital, Brussels, Belgium.
[Link to Abstract]


2004

DECEMBER

Efficacy of Selective Continuous Transarterial Infusion Chemotherapy on Advanced Pancreatic Cancer.
Zhou JX, Hong GB, Xu LY, Xu LF, Chen YT, Jiang RJ, Luo JH.
Ai Zheng. 2004 Dec;23(12):1677-80. Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
[Link to Abstract]

Fluorouracil, Doxorubicin, and Streptozocin in the Treatment of Patients with Locally Advanced and Metastatic Pancreatic Endocrine Carcinomas.
Kouvaraki MA, Ajani JA, Hoff P, Wolff R, Evans DB, Lozano R, Yao JC.
J Clin Oncol. 2004 Dec 1;22(23):4762-71. University of Texas / M.D. Anderson Cancer Center, Houston, Texas.
[Link to Abstract]

Gemcitabine Versus FLEC Regimen Given Intra-Arterially to Patients with Unresectable Pancreatic Cancer: A Prospective, Randomized Phase III Trial of the Italian Society for Integrated Locoregional Therapy in Oncology.
Cantore M, Fiorentini G, Luppi G, Rosati G, Caudana R, Piazza E, Comella G, Ceravolo C, Miserocchi L, Mambrini A, Del Freo A, Zamagni D, Rabbi C, Marangolo M.
J Chemother. 2004 Dec;16(6):589-94. Oncological Department, USL 1, Massa and Carrara, Italy.
[Link to Abstract]

Isolated Hepatic Perfusion for the Treatment of Patients with Advanced Liver Metastases from Pancreatic and Gastrointestinal Neuroendocrine Neoplasms.
Grover AC, Libutti SK, Pingpank JF, Helsabeck C, Beresnev T, Alexander HR Jr.
Surgery. 2004 Dec;136(6):1176-82. National Cancer Institute, Bethesda, Maryland.
[Link to Abstract]


NOVEMBER

Curative Resection for a Pancreatic Endocrine Carcinoma Involving the Portal Vein.
Sakamoto E, Hasegawa H, Ogiso S, Igami T, Mori T, Mizuno T, Hattori K, Sugimoto M, Fukami Y.
Hepatogastroenterology. 2004 Nov-Dec;51(60):1849-51. Nagoya Daini Red Cross Hospital, Nagoya, Japan.
[Link to Abstract]

Laparoscopic Pancreatic Surgery for Islet Cell Tumors of the Pancreas.
Assalia A, Gagner M.
World J Surg. 2004 Dec;28(12):1239-47. 2004 Nov 04. Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York City.
[Link to Abstract]

A Randomized Multicenter Trial Comparing Resection and Radiochemotherapy for Resectable Locally Invasive Pancreatic Cancer.
Imamura M, Doi R, Imaizumi T, Funakoshi A, Wakasugi H, Sunamura M, Ogata Y, Hishinuma S, Asano T, Aikou T, Hosotani R, Maetani S.
Surgery. 2004 Nov;136(5):1003-11. Kyoto University, Japan.
[Link to Abstract]

Sequential and/or Concurrent Hypofractionated Radiotherapy and Concurrent Chemotherapy in Neoadjuvant Treatment of Advanced Adenocarcinoma of The Pancreas. Outcome and Patterns of Failure.
Zimmermann FB, Schuhmacher C, Lersch C, Bernhardt B, Pickel P, Siewert JR, Molls M, Jeremic B.
Hepatogastroenterology. 2004 Nov-Dec;51(60):1842-6. Technische Universitaet Muenchen, Germany.
[Link to Abstract]

OCTOBER

Advances in the Genetic Screening, Work-Up, and Treatment of Pancreatic Cancer.
Frucht H, Stevens PD, Fogelman DR, Verna EC, Chen J, Chabot JA, Fine RL.
Curr Treat Options Gastroenterol. 2004 Oct;7(5):343-354. Columbia University, New York City.
[Link to Abstract]

A Case of Successful Management of Nonresectable Pancreas Cancer with Liver Metastasis by Intra-Arterial Infusion Chemotherapy with Gemcitabine Hydrochloride, 5-FU, CDDP and Administration of Tegafur/Uracil.
Ishikawa T, Mizuno K, Watanabe K, Baba Y, Oota H, Yoshida T, Kamimura T.
Gan To Kagaku Ryoho. 2004 Oct;31(10):1555-8. Saiseikai Niigata Second Hospital, Japan.
[Link to Abstract]

Phase I-II Trial of Twice-Weekly Gemcitabine and Concomitant Irradiation in Patients Undergoing Pancreaticoduodenectomy with Extended Lymphadenectomy for Locally Advanced Pancreatic Cancer.
Joensuu TK, Kiviluoto T, Karkkainen P, Vento P, Kivisaari L, Tenhunen M, Westberg R, Elomaa I.
Int J Radiat Oncol Biol Phys. 2004 Oct 1;60(2):444-52. Helsinki University Central Hospital, Finland.
[Link to Abstract]

A Phase II Trial of FUdR in Patients with Advanced Pancreatic Cancer.
Ardalan B, Lima M.
J Cancer Res Clin Oncol. 2004 Oct;130(10):561-6. University of Miami/Sylvester Comprehensive Cancer Center, Florida.
[Link to Abstract]

SEPTEMBER

Adjuvant Chemotherapy for Unresectable Locally Advanced Pancreatic Cancer in Light of Its Characteristics.
Taoka H, Hirano H, Mitsui Y, Umino W, Nobuoka Y, Yamashita M, Tanigawa K, Yoshimine S, Imai T, Kadowaki S, Miyashita K, Ikuma H, Nakamura T, Murata T.
Gan To Kagaku Ryoho. 2004 Sep;31(9):1365-70. HPB Interesting Group, Suzuka General Hospital, Japan.
[Link to Abstract]

Antiangiogenic Versus Cytotoxic Therapeutic Approaches to Human Pancreas Cancer: An Experimental Study with a Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor and Gemcitabine.
Bocci G, Danesi R, Marangoni G, Fioravanti A, Boggi U, Esposito I, Fasciani A, Boschi E, Campani D, Bevilacqua G, Mosca F, Del Tacca M.
Eur J Pharmacol. 2004 Sep 13;498(1-3):9-18. University of Pisa, Pisa, Italy.
[Link to Abstract]

Isolated Roux-Loop Pancreaticojejunostomy: A Series of 61 Patients with Zero Postoperative Pancreaticoenteric Leaks.
Sutton CD, Garcea G, White SA, O'Leary E, Marshall LJ, Berry DP, Dennison AR.
J Gastrointest Surg. 2004 Sep-Oct;8(6):701-5. Leicester General Hospital, Leicester, England.
[Link to Abstract]

Phase I Study of a MUC1 Vaccine Composed of Different Doses of MUC1 Peptide with SB-AS2 Adjuvant in Resected and Locally Advanced Pancreatic Cancer.
Ramanathan RK, Lee KM, McKolanis J, Hitbold E, Schraut W, Moser AJ, Warnick E, Whiteside T, Osborne J, Kim H, Day R, Troetschel M, Finn OJ.
Cancer Immunol Immunother. 2004 Sep 14. University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
[Link to Abstract]

AUGUST

5-Fluorouracil-Based Chemoradiation in Unresectable Pancreatic Carcinoma: Phase I-II Dose-Escalation Study.
Morganti AG, Valentini V, Macchia G, Mattiucci GC, Costamagna G, Deodato F, Smaniotto D, Luzi S, Balducci M, Barbi S, Perri V, Trodella L, Cellini N.
Int J Radiat Oncol Biol Phys. 2004 Aug 1;59(5):1454-60. Universita Cattolica del S. Cuore, Campobasso, Italy.
[Link to Abstract]

Adjuvant Therapy in Pancreatic Cancer: Phase I Trial of Radiation Dose Escalation with Concurrent Full-Dose Gemcitabine.
Allen AM, Zalupski MM, Robertson JM, Eckhauser FE, Simone D, Brown D, Hejna G, Normolle D, Lawrence TS, McGinn CJ.
Int J Radiat Oncol Biol Phys. 2004 Aug 1;59(5):1461-7. University of Michigan School of Medicine, Ann Arbor, Michigan.
[Link to Abstract]

Neoadjuvant Chemoradiation with Tegafur in Cancer of The Pancreas: Initial Analysis of Clinical Tolerance and Outcome.
Calvo FA, Matute R, Garcia-Sabrido JL, Gomez-Espi M, Martinez NE, Lozano MA, Herranz R.
Am J Clin Oncol. 2004 Aug;27(4):343-9. Hospital General Universitario Gregorio Maranon, Madrid, Spain.
[Link to Abstract]

A Phase I Trial of The Dual Farnesyltransferase and Geranylgeranyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Pancreatic Cancer.
Martin NE, Brunner TB, Kiel KD, DeLaney TF, Regine WF, Mohiuddin M, Rosato EF, Haller DG, Stevenson JP, Smith D, Pramanik B, Tepper J, Tanaka WK, Morrison B, Deutsch P, Gupta AK, Muschel RJ, McKenna WG, Bernhard EJ, Hahn SM.
Clin Cancer Res. 2004 Aug 15;10(16):5447-54. University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
[Link to Abstract]

JULY

Cetuximab, a Monoclonal Antibody Targeting the Epidermal Growth Factor Receptor, in Combination with Gemcitabine for Advanced Pancreatic Cancer: A Multicenter Phase II Trial.
Xiong HQ, Rosenberg A, LoBuglio A, Schmidt W, Wolff RA, Deutsch J, Needle M, Abbruzzese JL.
J Clin Oncol. 2004 Jul 1;22(13):2610-6. University of Texas / M.D. Anderson Cancer Center, Houston, Texas.
[Link to Abstract]

Gefitinib ('Iressa', ZD1839), A Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Inhibits Pancreatic Cancer Cell Growth, Invasion, and Colony Formation.
Li J, Kleeff J, Giese N, Buchler MW, Korc M, Friess H.
Int J Oncol. 2004 Jul;25(1):203-10. University of Heidelberg, Heidelberg, Germany.
[Link to Abstract]

A Phase II Trial of FudR in Patients with Advanced Pancreatic Cancer.
Ardalan B, Lima M.
J Cancer Res Clin Oncol. 2004 Jul 29. University of Miami / Sylvester Comprehensive Cancer Center, Miami, Florida.
[Link to Abstract]

Pilot Study of Celecoxib and Infusional 5-Fluorouracil as Second-Line Treatment for Advanced Pancreatic Carcinoma.
Milella M, Gelibter A, Di Cosimo S, Bria E, Ruggeri EM, Carlini P, Malaguti P, Pellicciotta M, Terzoli E, Cognetti F.
Cancer. 2004 Jul 1;101(1):133-8. Regina Elena National Cancer Institute, Rome, Italy.
[Link to Abstract]

JUNE

A Case of Advanced Pancreatic Cancer with Remarkable Response to Thalidomide, Celecoxib and Gemcitabine.
Hada M, Mizutari K.
Gan To Kagaku Ryoho. 2004 Jun;31(6):959-61. Ashitaka Hospital, Japan.
[Link to Abstract]

Gemcitabine Combined with Infusional 5-Fluorouracil and High-Dose Leucovorin for The Treatment of Advanced Carcinoma of The Pancreas.
Oztop I, Yilmaz U, Yavuzsen T, Yaren A, Tarhan O, Sagol O, Coker A, Alakavuklar M.
Chemotherapy. 2004 Jun;50(3):127-32. University of Dokuz Eylul, Izmir, Turkey.
[Link to Abstract]

Intensity-Modulated Radiotherapy (IMRT) and Concurrent Capecitabine for Pancreatic Cancer.
Ben-Josef E, Shields AF, Vaishampayan U, Vaitkevicius V, El-Rayes BF, McDermott P, Burmeister J, Bossenberger T, Philip PA.
Int J Radiat Oncol Biol Phys. 2004 Jun 1;59(2):454-9. Wayne State University and the Karmanos Cancer Institute, Detroit, Michigan.
[Link to Abstract]

Intraductal Papillary Mucinous Neoplasms of the Pancreas: An Updated Experience.
Sohn TA, Yeo CJ, Cameron JL, Hruban RH, Fukushima N, Campbell KA, Lillemoe KD.
Ann Surg. 2004 Jun;239(6):788-97; discussion 797-9. Johns Hopkins Medical Institutions, Baltimore, Maryland.
[Link to Abstract]

MAY

5-Fluorouracil or Gemcitabine Combined with Adenoviral-Mediated Reintroduction of P16ink4a Greatly Enhanced Cytotoxicity in Panc-1 Pancreatic Adenocarcinoma Cells.
Halloran CM, Ghaneh P, Shore S, Greenhalf W, Zumstein L, Wilson D, Neoptolemos JP, Costello E.
J Gene Med. 2004 May;6(5):514-25. Royal Liverpool University Hospital, Liverpool, UK.
[Link to Abstract]

Fine Needle Aspiration Cytology of Endocrine Neoplasms of The Pancreas. Morphologic and Immunocytochemical Findings in 20 Cases.
Jimenez-Heffernan JA, Vicandi B, Lopez-Ferrer P, Gonzalez-Peramato P, Perez-Campos A, Viguer JM.
Acta Cytol. 2004 May-Jun;48(3):295-301. Department of Pathology, University Hospital, Guadalajara, Spain.
[Link to Abstract]

Islet Autotransplantation Combined with Pancreatectomy for Treatment of Pancreatic Adenocarcinoma: A Case Report.
Forster S, Liu X, Adam U, Schareck WD, Hopt UT.
Transplant Proc. 2004 May;36(4):1125-6. University of Rostock, Germany; University of Freiburg, Germany.
[Link to Abstract]

Pancreaticoduodenectomy with En Bloc Portal Vein Resection for Pancreatic Carcinoma with Suspected Portal Vein Involvement.
Poon RT, Fan ST, Lo CM, Liu CL, Lam CM, Yuen WK, Yeung C, Wong J.
World J Surg. 2004, May 6. Queen Mary Hospital, University of Hong Kong Medical Centre, China.
[Link to Abstract]

APRIL

Pancreatic Cancer Registry in Japan: 20 Years of Experience.
Matsuno S, Egawa S, Fukuyama S, Motoi F, Sunamura M, Isaji S, Imaizumi T, Okada S, Kato H, Suda K, Nakao A, Hiraoka T, Hosotani R, Takeda K.
Pancreas. 2004 Apr;28(3):219-30. Tohoku University Graduate School of Medicine, Sendai, Japan.
[Link to Abstract]

Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds.
Klein AP, Brune KA, Petersen GM, Goggins M, Tersmette AC, Offerhaus GJ, Griffin C, Cameron JL, Yeo CJ, Kern S, Hruban RH.
Cancer Res. 2004 Apr 1;64(7):2634-8. National Human Genome Research Institute, NIH, Baltimore, Maryland.
[Link to Abstract]

Time Interval Between Abnormalities Seen on CT and the Clinical Diagnosis of Pancreatic Cancer: Retrospective Review of CT Scans Obtained Before Diagnosis.
Gangi S, Fletcher JG, Nathan MA, Christensen JA, Harmsen WS, Crownhart BS, Chari ST.
AJR Am J Roentgenol. 2004 Apr;182(4):897-903. University of Medicine and Dentistry of New Jersey, Newark, New Jersey.
[Link to Abstract]