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Kosan and Roche Present Favorable Phase I Results of KOS-862 (Epothilone D), at the American Society of Clinical Oncology Annual Meeting
June 2, 2003

Kosan Biosciences Incorporated and Roche announced today results of the initial Phase I clinical trial of KOS-862 (Epothilone D) at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, IL. KOS-862 is a polyketide natural product that inhibits cancer cells by the same mechanism as paclitaxel, and is also effective against paclitaxel-resistant tumors in preclinical models. The poster entitled "KOS-862 (Epothilone D): A Comparison of Two Schedules in Patients with Advanced Malignancies" will be presented today, from 9:00 a.m. to 1:00 p.m., Central Time, at the McCormick Convention Center.

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